GGD 37: An Extreme Protostellar Outflow

We present the first Spitzer-IRS spectral maps of the Herbig-Haro flow GGD 37 detected in lines of [Ne III], [O IV], [Ar III], and [Ne v]. The detection of extended [O IV] (55 eV) and some extended emission in [Ne v] (97 eV) indicates a shock temperature in excess of 100,000 K, in agreement with X-ray observations, and a shock speed in excess of 200 km s(-1). The presence of an extended photoionization or collisional ionization region indicates that GGD 37 is a highly unusual protostellar outflow.Jet Propulsion Laboratory, under NASA 1407NASA 1257184Jet Propulsion Laboratory (JPL) 960803University of Rochester 31419-5714Astronom

Malware Target Recognition via Static Heuristics

Organizations increasingly rely on the confidentiality, integrity and availability of their information and communications technologies to conduct effective business operations while maintaining their competitive edge. Exploitation of these networks via the introduction of undetected malware ultimately degrades their competitive edge, while taking advantage of limited network visibility and the high cost of analyzing massive numbers of programs. This article introduces the novel Malware Target Recognition (MaTR) system which combines the decision tree machine learning algorithm with static heuristic features for malware detection. By focusing on contextually important static heuristic features, this research demonstrates superior detection results. Experimental results on large sample datasets demonstrate near ideal malware detection performance (99.9+% accuracy) with low false positive (8.73e-4) and false negative rates (8.03e-4) at the same point on the performance curve. Test results against a set of publicly unknown malware, including potential advanced competitor tools, show MaTR’s superior detection rate (99%) versus the union of detections from three commercial antivirus products (60%). The resulting model is a fine granularity sensor with potential to dramatically augment cyberspace situation awareness

Efficient Implementation and the Product State Representation of Numbers

The relation between the requirement of efficient implementability and the product state representation of numbers is examined. Numbers are defined to be any model of the axioms of number theory or arithmetic. Efficient implementability (EI) means that the basic arithmetic operations are physically implementable and the space-time and thermodynamic resources needed to carry out the implementations are polynomial in the range of numbers considered. Different models of numbers are described to show the independence of both EI and the product state representation from the axioms. The relation between EI and the product state representation is examined. It is seen that the condition of a product state representation does not imply EI. Arguments used to refute the converse implication, EI implies a product state representation, seem reasonable; but they are not conclusive. Thus this implication remains an open question.Comment: Paragraph in page proof for Phys. Rev. A revise

In Vivo and In Vitro Pharmacological Studies of Methoxycarbonyl-Carboetomidate

Background—We previously developed two etomidate analogs that retain etomidate’s favorable hemodynamic properties, but whose adrenocortical effects are reduced in duration or magnitude. Methoxycarbonyl-etomidate (MOC-etomidate) is rapidly metabolized and ultra-short acting whereas (R)-ethyl 1-(1-phenylethyl)-1H-pyrrole-2-carboxylate (carboetomidate) does not potently inhibit 11?-hydroxylase. We hypothesized that MOC-etomidate’s labile ester could be incorporated into carboetomidate to produce a new agent that possesses favorable properties individually found in each agent. We describe the synthesis and pharmacology of methoxycarbonyl-(R)-ethyl 1-(1-phenylethyl)-1H-pyrrole-2-carboxylate (MOC-carboetomidate), a “soft” analog of carboetomidate. Methods—MOC-carboetomidate’s octanol:water partition coefficient was determined chromatographically and compared with those of etomidate, carboetomidate, and MOC-etomidate. MOC-carboetomidate’s EC50 and ED50 for loss of righting reflexes (LORR) were measured in tadpoles and rats, respectively. Its effect on gamma-aminobutyric acid A (GABAA) receptor function was assessed using two-microelectrode voltage clamp electrophysiological techniques and its metabolic stability was determined in pooled rat blood using high performance liquid chromatography. Its duration of action and effects on arterial blood pressure and adrenocortical function were assessed in rats. Results—MOC-carboetomidate’s octanol:water partition coefficient was 3300 ± 280, whereas those for etomidate, carboetomidate, and MOC-etomidate were 800 ± 180, 15000 ± 3700, and 190 ± 25, respectively. MOC-carboetomidate’s EC50 for LORR in tadpoles was 9 ± 1 µM and its EC50 for LORR in rats was 13 ± 5 mg/kg. At 13 µM, MOC-carboetomidate enhanced GABAA receptor currents by 400 ± 100%. Its metabolic half-life in pooled rat blood was 1.3 minutes. The slope of a plot of the duration of LORR in rats versus the logarithm of the hypnotic dose was significantly shallower for MOC-carboetomidate than for carboetomidate (4 ± 1 vs. 15 ± 3, respectively; p = 0. 0004123). At hypnotic doses, the effects of MOC-carboetomidate on arterial blood pressure and adrenocortical function were not significantly different from those of vehicle alone. Conclusions—MOC-carboetomidate is a GABAA receptor modulator with potent hypnotic activity that is more rapidly metabolized and cleared from the brain than carboetomidate, maintains hemodynamic stability similar to carboetomidate, and does not suppress adrenocortical function

Myosin X and its motorless isoform differentially modulate dendritic spine development by regulating trafficking and retention of vasodilator-stimulated phosphoprotein

Myosin X (Myo10) is an unconventional myosin with two known isoforms: full-length (FL)-Myo10 that has motor activity, and a recently identified brain-expressed isoform, headless (Hdl)-Myo10, which lacks most of the motor domain. FL-Myo10 is involved in the regulation of filopodia formation in non-neuronal cells; however, the biological function of Hdl-Myo10 remains largely unknown. Here, we show that FL- and Hdl-Myo10 have important, but distinct, roles in the development of dendritic spines and synapses in hippocampal neurons. FL-Myo10 induces formation of dendritic filopodia and modulates filopodia dynamics by trafficking the actin-binding protein vasodilator-stimulated phosphoprotein (VASP) to the tips of filopodia. By contrast, Hdl-Myo10 acts on dendritic spines to enhance spine and synaptic density as well as spine head expansion by increasing the retention of VASP in spines. Thus, this study demonstrates a novel biological function for Hdl-Myo10 and an important new role for both Myo10 isoforms in the development of dendritic spines and synapses

The Representation of Natural Numbers in Quantum Mechanics

This paper represents one approach to making explicit some of the assumptions and conditions implied in the widespread representation of numbers by composite quantum systems. Any nonempty set and associated operations is a set of natural numbers or a model of arithmetic if the set and operations satisfy the axioms of number theory or arithmetic. This work is limited to k-ary representations of length L and to the axioms for arithmetic modulo k^{L}. A model of the axioms is described based on states in and operators on an abstract L fold tensor product Hilbert space H^{arith}. Unitary maps of this space onto a physical parameter based product space H^{phy} are then described. Each of these maps makes states in H^{phy}, and the induced operators, a model of the axioms. Consequences of the existence of many of these maps are discussed along with the dependence of Grover's and Shor's Algorithms on these maps. The importance of the main physical requirement, that the basic arithmetic operations are efficiently implementable, is discussed. This conditions states that there exist physically realizable Hamiltonians that can implement the basic arithmetic operations and that the space-time and thermodynamic resources required are polynomial in L.Comment: Much rewrite, including response to comments. To Appear in Phys. Rev.

A mathematical model for fibro-proliferative wound healing disorders

The normal process of dermal wound healing fails in some cases, due to fibro-proliferative disorders such as keloid and hypertrophic scars. These types of abnormal healing may be regarded as pathologically excessive responses to wounding in terms of fibroblastic cell profiles and their inflammatory growth-factor mediators. Biologically, these conditions are poorly understood and current medical treatments are thus unreliable. In this paper, the authors apply an existing deterministic mathematical model for fibroplasia and wound contraction in adult mammalian dermis (Olsenet al., J. theor. Biol. 177, 113–128, 1995) to investigate key clinical problems concerning these healing disorders. A caricature model is proposed which retains the fundamental cellular and chemical components of the full model, in order to analyse the spatiotemporal dynamics of the initiation, progression, cessation and regression of fibro-contractive diseases in relation to normal healing. This model accounts for fibroblastic cell migration, proliferation and death and growth-factor diffusion, production by cells and tissue removal/decay. Explicit results are obtained in terms of the model processes and parameters. The rate of cellular production of the chemical is shown to be critical to the development of a stable pathological state. Further, cessation and/or regression of the disease depend on appropriate spatiotemporally varying forms for this production rate, which can be understood in terms of the bistability of the normal dermal and pathological steady states—a central property of the model, which is evident from stability and bifurcation analyses. The work predicts novel, biologically realistic and testable pathogenic and control mechanisms, the understanding of which will lead toward more effective strategies for clinical therapy of fibro-proliferative disorders

A Mercury Lander Mission Concept Study for the Next Decadal Survey

Mariner 10 provided our first closeup reconnaissance of Mercury during its three flybys in 1974 and 1975. MESSENGERs 20112015 orbital investigation enabled numerous discoveries, several of which led to substantial or complete changes in our fundamental understanding of the planet. Among these were the unanticipated, widespread presence of volatile elements (e.g., Na, K, S); a surface with extremely low Fe abundance whose darkening agent is likely C; a previously unknown landformhollows that may form by volatile sublimation from within rocks exposed to the harsh conditions on the surface; a history of expansive effusive and explosive volcanism; substantial radial contraction of the planet from interior cooling; offset of the dipole moment of the internal magnetic field northward from the geographic equator by ~20% of the planets radius; crustal magnetization, attributed at least in part to an ancient field; unexpected seasonal variability and relationships among exospheric species and processes; and the presence in permanently shadowed polar terrain of water ice and other volatile materials, likely to include complex organic compounds. Mercurys highly chemically reduced and unexpectedly volatile-rich composition is unique among the terrestrial planets and was not predicted by earlier hypotheses for the planets origin. As an end-member of terrestrial planet formation, Mercury holds unique clues about the original distribution of elements in the earliest stages of the Solar System and how planets (and exoplanets) form and evolve in close proximity to their host stars. The BepiColombo mission promises to expand our knowledge of this planet and to shed light on some of the mysteries revealed by the MESSENGER mission. However, several fundamental science questions raised by MESSENGERs pioneering exploration of Mercury can only be answered with in situ measurements from the planets surface

Heating of Heavy Ions by Interplanetary Coronal Mass Ejection (ICME) Driven Collisionless Shocks

Shock heating and particle acceleration processes are some of the most fundamental physical phenomena of plasma physics with countless applications in laboratory physics, space physics, and astrophysics. This study is motivated by previous observations of non-thermal heating of heavy ions in astrophysical shocks (Korreck et al. 2004). Here, we focus on shocks driven by Interplanetary Coronal Mass Ejections (ICMEs) which heat the solar wind and accelerate particles. This study focuses specifically on the heating of heavy ions caused by these shocks. Previous studies have focused only on the two dynamically dominant species, H+ and He2+ . This study utilizes thermal properties measured by the Solar Wind Ion Composition Spectrometer (SWICS) aboard the Advanced Composition Explorer (ACE) spacecraft to examine heavy ion heating. This instrument provides data for many heavy ions not previously available for detailed study, such as Oxygen (O6+, O7+), Carbon (C5+, C6+), and Iron (Fe10+). The ion heating is found to depend critically on the upstream plasmaComment: accepted Ap